1. MITOCHONDRIAL REPLACEMENT THERAPY (MRT)
2. STEM CELL / EXOSOME REJUVENATION
3. IVF & EGG FREEZING
Evidence-driven fertility care with personalized protocols and compassionate support.
1. MITOCHONDRIAL REPLACEMENT THERAPY (MRT)
What it is
Mitochondria is the power the egg. With age, mitochondrial function declines, which reduces egg quality and embryo development.
Mitochondrial Replacement Therapy (MRT) replaces the egg’s impaired mitochondria with healthy mitochondria from a donor egg, while keeping your nuclear DNA.
Dr. Zaher Merhi contributed to the team behind the world’s first MRT baby (Mexico).
Benefits & considerations
Benefits
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Aims to improve egg energy and embryo quality
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Preserves your genetic identity (nuclear DNA)
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Conducted in a high-tech IVF lab at RFC Bahamas.
Considerations
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Clinical MRT is not available in the U.S. (current federal restriction on FDA review)
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Performed only where local regulations allow - Our Bahamas Location.
Who it’s for
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Advanced maternal age
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Low / diminished ovarian reserve (low AMH / high FSH)
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Poor egg or embryo quality despite prior IVF
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Menopause or Premature Ovarian Insufficiency/Failure (POI/POF)
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Patients seeking a biologically related child at any age using their own nuclear DNA
How it’s done
Before your trip
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Medical counseling to confirm eligibility
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Collect and freeze your eggs (egg freezing) and sperm
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Donor eggs are sourced and prepared for healthy mitochondria
In the Bahamas
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Your eggs are carefully combined with donor egg mitochondria
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The reconstructed eggs mature and are fertilized in our IVF lab
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Healthy embryos are frozen for later transfer — usually done in one visit
2. STEM CELL / EXOSOME REJUVENATION
What it is
Exosomes are tiny extracellular vesicles released by mesenchymal stem cells (MSC) that carry proteins, lipids, and RNA—key signals for cell-to-cell communication. Rather than infusing donor stem cells, exosome therapy uses purified, sterilized exosomes sourced from FDA-approved U.S. suppliers and administered to target tissues to support cellular repair and signaling.
Benefits & considerations
Benefits
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Powerful cell-signaling support (exosomes contain high growth-factor content—often reported ~3× vs. adult stem cells)
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Anti-inflammatory & anti-fibrotic actions
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Flexible targeting (ovary, uterus, vagina)
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Not all patients are candidates; a medical review is required
Who it’s for
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Menopause
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Premature Ovarian Insufficiency (POI)
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Low/Diminished Ovarian Reserve (low AMH, high FSH)
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Poor egg/embryo quality
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Thin or poor-quality endometrium
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Failed implantation / chemical pregnancy
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Asherman’s syndrome
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Recurrent miscarriage related to lining issues
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Vaginal dryness or discomfort with intercourse
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Low libido
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Excessive vaginal laxity
How it’s done
Exosome vials (and/or stem cells) are purchased from the U.S. then shipped, stored at RFC Bahamas.
Ultrasound-guided injections:
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Ovaries and/or uterus and/or vagina receive targeted exosome injections.
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Anesthesia is typically used; most patients go home the same day.
3. IVF & EGG FREEZING
What it is
IVF at RFC includes Personalized IVF, Natural IVF, and Mini-IVF, as well as egg and embryo freezing. Protocols are adapted for women with low AMH, high FSH, PCOS, or prior poor response to conventional IVF—aiming for quality embryos with minimal burden.
Benefits & considerations
Benefits
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Tailored stimulation (including gentle or no-stim options)
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Option to test embryos (PGT)
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Fertility preservation (eggs/embryos)
Considerations
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Multiple visits for monitoring
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Ovarian stimulation side-effects vary
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Not all eggs fertilize or lead to embryos
Who it’s for
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Women planning pregnancy now or later (fertility preservation)
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Low ovarian reserve (low AMH / high FSH)
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PCOS
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Prior poor response to stimulation
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Those preferring low-stimulation or natural-cycle options
How it’s done
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Consult & labs – history, ultrasound, AMH/FSH and tailored plan.
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Stimulation (if chosen) – conventional, mini, or natural monitoring.
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Egg retrieval – brief procedure under sedation.
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Fertilization & embryo culture – ICSI/standard; option for PGT.
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Transfer or freezing – embryo transfer now, or freeze embryos/eggs for later.
Scientific References
1. Mitochondrial Replacement Therapy (MRT)
Zhang, J., Liu, H., Luo, S., Lu, Z., Chávez-Badiola, A., Liu, Z., Yang, M., Merhi, Z., Silber, S. J., Munné, S., Konstantinidis, M., Wells, D., Tang, J. J., & Huang, T. (2017). Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reproductive biomedicine online, 34(4), 361–368. https://doi.org/10.1016/j.rbmo.2017.01.013
2. Exosome-focused ovarian rejuvenation
Cui, X., Li, H., Huang, X., Xue, T., Wang, S., Zhu, X., & Jing, X. (2025). Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure. Journal of ovarian research, 18(1), 216. https://doi.org/10.1186/s13048-025-01785-1
Tang, Y., He, Y., Huo, X., Chen, J., Qian, M., Huang, H., Meng, Y., Zhang, L., Xu, F., Zhang, Y., Bao, H., & Xiong, Y. (2025). hUMSC-derived exosomes alleviate follicular interstitial cell autophagy by let-7a-5p/AMPK/mTOR axis in POI rats. Stem cell research & therapy, 16(1), 291. https://doi.org/10.1186/s13287-025-04396-1
Chen, W., Feng, Q., Zhang, C., Yang, L., & Qi, J. (2025). Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway. Reproductive medicine and biology, 24(1), e12658. https://doi.org/10.1002/rmb2.12658
Ji, G., Wang, P., Kong, Z., Cao, X., Sun, Z., Yang, J., Zhao, X., Feng, H., & Hu, H. (2025). Human umbilical cord mesenchymal stem cells recover chemotherapy-induced premature ovarian failure. Frontiers in medicine, 12, 1681233. https://doi.org/10.3389/fmed.2025.1681233
Huang, C., Kong, N., Xue, P., Zhang, H., Ding, L., Wang, L., Zhou, J., Xing, J., Mei, J., & Sun, H. (2025). Transplantation of UC-MSCs in ovary improves ovarian function and intermediate outcomes in IVF/ICSI cycles of POI patients: a clinical cohort study. Stem cell research & therapy, 16(1), 552. https://doi.org/10.1186/s13287-025-04680-0