SUPER Ovarian Rejuvenation in The Bahamas
World Exclusive · Available Only at RFC Nassau
Super Ovarian Rejuvenation is the world's first fertility protocol to combine four regenerative therapies — patient's own adipose (fat) stem cells, platelet-rich plasma (PRP), umbilical cord stem cells, and exosomes — in a single procedure.
Unlike treatments that use just one or two regenerative components, this comprehensive approach delivers all four directly to the ovaries during the same one visit, maximizing the regenerative effect for women with diminished ovarian reserve, premature ovarian insufficiency (POI), and menopause or those who haven't responded to PRP ovarian rejuvenation alone.
Available exclusively at RFC Nassau, Bahamas — performed by Dr. Zaher Merhi, a global leader in ovarian rejuvenation.
How Super Ovarian Rejuvenation Works
Super Ovarian Rejuvenation works by combining four distinct regenerative therapies, each with its own mechanism, into one biologic preparation that is delivered directly to both ovaries under ultrasound guidance. By layering these mechanisms, the protocol aims to support follicle health, reduce inflammation, and restore ovarian function more comprehensively than any single therapy can on its own.
1) Adipose-Derived Regenerative Cells
Dr Merhi publlished the first live births in the wrold following Adipose stem cells. A small amount of fat tissue is collected from the patient's lower abdomen via mini-liposuction (under 1 cm entry point). This tissue is rich in mesenchymal stem cells and growth factors. After extraction, the regenerative cells are isolated and added to the combined preparation. Adipose-derived cells may help:
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Reduce inflammation in the ovarian environment
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Support ovarian tissue repair and regeneration
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Improve the local hormonal microenvironment
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Provide growth factors that support follicular activity for betterr egg qualify
2) Platelet-Rich Plasma (PRP)
PRP is prepared from the patient's own blood. A small sample is drawn and processed in a centrifuge to concentrate platelets, which carry growth factors and cytokines. Once concentrated, the PRP is added to the combined preparation. PRP may help:
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Stimulate dormant follicles toward activity
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Improve blood flow to the ovary
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Support tissue healing and follicular response
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Provide a high concentration of platelet-derived growth factors
3) Mesenchymal Stem Cells (MSCs)
Ethically sourced mesenchymal stem cells are purchased from a USA-based company and shipped to the Bahamas under strict safe quality controls. These cells act as biological support cells, releasing signaling molecules that may support tissue repair. MSCs may help:
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Reduce inflammation
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Improve blood flow to the ovary
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Support tissue repair and regeneration
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Improve the ovarian microenvironment & egg qualify
4) Exosomes
Exosomes are tiny signaling particles naturally released by stem cells. They carry proteins and growth factors that help cells communicate and repair tissue. One advantage of exosomes is that they do NOT contain nuclear DNA. When delivered to the ovary, exosomes may help:
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Reduce inflammation and oxidative stress
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Decrease tissue scarring (fibrosis)
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Support cell survival and ovarian health
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Provide regenerative signaling without introducing living cells
The Combined Effect
By delivering all four regenerative therapies in a single procedure, Super Ovarian Rejuvenation aims to layer multiple mechanisms simultaneously: cellular signaling from exosomes, structural support from stem cells, growth-factor stimulation from PRP, and the dense regenerative cell content from adipose tissue. This may support healthier follicle development, hormonal balance, and improved ovarian function more comprehensively than any single therapy alone — particularly in women who haven't responded sufficiently to PRP or Adipose-PRP rejuvenation.
Who It May Benefit
✔️ Women older than 40
✔️ Diminished ovarian reserve (low AMH, high FSH)
✔️ Premature ovarian insufficiency (POI)
✔️ Menopause or perimenopause
✔️ Poor egg or embryo quality in prior IVF cycles
✔️ Women who tried PRP ovarian rejuvenation and didn't see improvement
✔️ Women who tried Adipose-PRP and want a more comprehensive option
✔️ Repeated IVF failures with poor ovarian response
✔️ Women who want their last best option before donor eggs
✔️ Patients traveling for treatment who want maximum benefit in one trip
Potential Benefits & Considerations
Benefits
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The world's first and only protocol combining all four regenerative therapies in a single procedure
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Layered mechanisms — cellular signaling, structural support, growth-factor stimulation, and regenerative cell delivery — in one visit
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All four components delivered directly to the ovaries under ultrasound guidance
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Performed in a single procedure (~2.5 hours) rather than staged across multiple visits
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Reported pregnancies in women over 40 using their own eggs after the protocol
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Can be combined with IVF (Mini-IVF, Natural, or Conventional) following recovery
Considerations
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Available exclusively at RFC Nassau — requires travel to the Bahamas
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Not all patients are candidates; comprehensive medical review required
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Results vary widely; not a guaranteed pregnancy
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Improvement may take several weeks to a few months to become visible
Scientific References
1. Adipose-derived stem cells & PRP for ovarian rejuvenation
Merhi Z, et al. (2025). First live births after adipose-derived stem cells and platelet-rich plasma intra-ovarian administration. American Journal of Stem Cells, 14(5), 277. https://pmc.ncbi.nlm.nih.gov/articles/PMC12816867/
Merhi Z. (2025). Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments. Future Science OA, 11(1), 2580233. https://pmc.ncbi.nlm.nih.gov/articles/PMC12574566/
Merhi Z, Garg B, Haroun J. (2025). Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility. Frontiers in Endocrinology (Lausanne), 16, 1694025. https://pmc.ncbi.nlm.nih.gov/articles/PMC12582987/
2. Platelet-rich plasma in reproductive medicine
Merhi Z, Wiltshire McLeod C, Shamim F. (2025). Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications. Biomedicines, 13(10), 2488. https://pmc.ncbi.nlm.nih.gov/articles/PMC12561688/
Merhi Z, Mouanness M. (2022). Ovarian response to intra-ovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms. Journal of Assisted Reproduction and Genetics, 39, 37–61. https://pmc.ncbi.nlm.nih.gov/articles/PMC8866624/
3. Stem cells & exosomes for ovarian function
Cui X, Li H, Huang X, Xue T, Wang S, Zhu X, Jing X. (2025). Exosomes derived from mesenchymal stem cells repair ovarian function by suppressing NLRP3-mediated pyroptosis in cyclophosphamide-induced premature ovarian failure. Journal of Ovarian Research, 18(1), 216. https://doi.org/10.1186/s13048-025-01785-1